Comparison of the Estimation on Glomerular Filtration Rate between Chronic Kidney Disease Epidemiology Collaboration （CKD-EPI） Equation and Gate’s Equation
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摘要: 目的 探讨联合肌酐和胱抑素C的慢性肾脏病流行病合作组方程和Gate’s法计算高龄 （年龄≥80岁）老年人肾小球滤过率的适用性。 方法 收集99例一般高龄老年人的临床资料,以双血浆法所测得肾小球滤过率为标准,分别用慢性肾脏病流行病合作组方程和Gate’s法计算肾小球滤过率,比较两者的估计偏差、精确性、准确性和95%的一致性。 结果 慢性肾脏病流行病合作组方程比Gate’s法降低了偏差（P=0.000）,提高了精确度,15%、30%和50%准确性（P=0.000、0.000、0.004）以及95%一致性,差异有统计学意义。 结论 对于高龄老年人,在不需要了解双肾形态、血流灌注状态及单侧肾功能的情况下,慢性肾脏病流行病合作组方程可能是较好的选择。Abstract: Objective To compare the applicability of the combined creatinine-cystatin C equation （CKD-EPIscr-cys） of the Chronic Kidney Disease Epidemiology Collaboration （CKD-EPI） and the Gate’s equation based on the renal dynamic imaging for estimating glomerular filtration rate （GFR） among the elderly patients （age≥80 years old）. Methods The GFR of 99 patients at the age of 80 and over were measured by the two-sample method and as standard. Then,Chronic Kidney Disease Epidemiology Collaboration equation and Gate’s equation were used to determine GFR simultaneously the differences of the two equations in deviation, accuracy, veracity and consistency of GFR prediction. Results Compared with the Gate’s equation, Chronic Kidney Disease Epidemiology Collaboration equation reduce the deviation（P=0.000）, improve the accuracy, 15%, 30% and 50% veracity（P=0.000, 0.000, 0.004） and 95% consistency with statistically significant difference. Conclusions Chronic Kidney Disease Epidemiology Collaboration equation might be a better method to evaluate the GFR of elders without measuring the parameter of morphology and hemodynamics and unilateral renal function.
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