Abstract: Low frequency pulsed electromagnetic fields is a non-invasive and safe physical therapy, and it has been used as a clinical adjuvant treatment of bone fracture, osteoarthritis, femur head necrosis, osteoporosis and cartilage injury. In addition to the effect of promoting fracture healing and the proliferation of chondrocytes, and increasing bone density, recent researches have shown that low frequency pulsed electromagnetic fields have the potential to treat neurological disease and ameliorate nerve injury symptoms. Therefore, this paper reviewed the progress of efficacy and mechanism of low frequency pulsed electromagnetic fields on stroke, Parkinson’s disease and multiple sclerosis, so as to provide some new idea for the treatment of the diseases.