Abstract: Objective To explore the correlation between the oral contraceptives（OCs） and the risk of Crohn’s disease （CD）. Methods Databases including PubMed, EMBASE, CNKI and Wanfang data were searched from inception to November 10,2017 to collect the cohort studies and case-control studies on the correlation between oral contraceptives and the risk of Crohn’s disease. The studies were screened according to the inclusion and exclusion criteria by two researchers independently, the data was extracted and the quality was evaluated. Meta-analysis was performed using Stata 13.0 software. Results A total of 17 literatures involving 308 747 participants were included. The results of meta-analysis showed that the pooled OR for the risk of CD for women taking the OCs was 1.4295%CI（1.24,1.61）,P<0.001, in the subgroup analysis,the OR for the risk of CD in women currently taking the OCs was 2.0795%CI （1.27,3.38）,P=0.004, and 1.1795%CI（1.07,1.74）,P=0.027 for women used in the past. Conclusion This study provides evidence of an association between the use of oral contraceptives and the onset risk of CD. The study also showed that the risk for patients who stop using the OCs decreased. But the study did not find time-effect relationship or dose-effect relationship for lack of sufficient data.