NSFC资助中医药领域发表的中文动物实验方法学质量的回顾性分析

周罡; 廖绪亮; 赵梦娜; 许家科; 闫琼; 王欢; 李彦佑; 戚世媛; 侯皓中; 朱敏; 马彬

doi:10.12019/j.issn.1671-5144.2019.03.012

NSFC资助中医药领域发表的中文动物实验方法学质量的回顾性分析

周罡¹,
廖绪亮^2,3,
赵梦娜^2,4,
许家科^2,4,
闫琼^2,4,
王欢^2,4,
李彦佑^2,3,
戚世媛^2,3,
侯皓中^2,3,
朱敏^2,4,
马彬^2,5, ,

1.
甘肃省人民医院心内科干部病房, 兰州 730000
2.
兰州大学循证医学中心、兰州大学基础医学院, 兰州 730000
3.
兰州大学第二临床医学院, 兰州 730000
4.
兰州大学第一临床医学院, 兰州 730000
5.
甘肃省循证医学与临床转化重点实验室,兰州 730000

基金项目: 国家自然科学基金资助项目（81303147）

详细信息

作者简介:
周罡和廖绪亮为共同第一作者。周罡（1980-）,男,兰州人,主治医师,硕士研究生,以心血管疾病机制及诊疗为主要研究方向。廖绪亮（1997-）,男,四川德阳人,本科生,以临床医学和系统评价方法学为主要研究方向。

通讯作者:
马彬, Tel: 13919988858, E-mail: mab@lzu.edu.cn

中图分类号: R181.2⁺4;R2
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出版历程
- 收稿日期: 2018-02-28
- 发布日期: 2019-06-27

The Methodological Quality of NSFC-Funded Animal Experiments in The Field of Traditional Chinese Medicine Published in Chinese Journals: A Retrospective Study

ZHOU Gang¹,
LIAO Xu-liang^2,3,
ZHAO Meng-na^2,4,
XU Jia-ke^2,4,
YAN Qiong^2,4,
WANG Huan^2,4,
LI Yan-you^2,3,
QI Shi-yuan^2,3,
HOU Hao-zhong^2,3,
ZHU Min^2,4,
MA Bin^2,5, ,

1.
Department of Cardiology, Gansu Provincial Hospital, Lanzhou 730000, China
2.
Evidence-Based Medicine Center of Lanzhou University, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China
3.
The Second Clinical Medical College of Lanzhou University, Lanzhou 730000, China
4.
The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China
5.
China Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou 730000, China

摘要

摘要: 目的基于SYRCLE动物实验偏倚风险评估工具,对国内中医药领域发表的由国家自然科学基金资助的动物实验的方法学质量及其存在的问题进行回顾性分析,为后续研究的设计和实施提供参考依据,以促进国内动物实验研究质量的提升。方法计算机检索中国科学引文数据库,检索时间限定为2011-2016年。由4名研究者独立筛选和提取资料,并交叉核对。组间比较采用卡方检验,检验水准α=0.05。结果最终纳入971篇研究,其中50.8%的研究被引次数为零,资助类型和学科中所占比例最高分别为面上项目（57.0%,553/971）和中医药领域H27（32%,316/971）。基于SYRCLE工具的评价结果显示: 超过一半的亚条目（68.2%,15/22）的“低风险”符合率低于60%,甚至其中73.3%（11/15）的亚条目的“低风险”符合率低于10%。此外,随着SYRCLE工具的发布,大部分亚条目的“低风险”符合率并未得到提高（P>0.05）。结论国内中医药领域目前发表的由国家自然科学基金资助的动物实验的方法学质量较低,而且随着SYRCLE动物试验偏倚风险评估工具的发布,其方法学质量并未得到改善和提高。
- 中医药 /
- 动物实验 /
- 方法学质量 /
- 国家自然科学基金
Abstract: Objective To provide references for the design and implementation of follow-up animal experiments and finally promote the transformation and utilization of its results, we made a retrospective analysis entirely of the quality of animal experiment methods and the existing problems in NSFC-funded Chinese medicine field by means of SYRCLE bias risk tool. Methods Four independent researchers extracted the data and cross-checked. Chi-square test were used for comparison between groups, and level of test was α=0.05. Results The final results include 971 researches in which the proportion of researches that weren't cited was 50.8%. The proportion of general program（57.0%,553/971） and H27 （32%, 316/971） were the highest in the funding categories and disciplines. Based on the results, we can see a majority of the sub-entries （68.2%, 15/22） are below 60% of the “low risk” compliance rate, and even 73.3% （11/15） of the sub-entries are below 10%. Besides, with the publication of the SYRCLE bias risk tool, a majority of the sub-entries have not been improved at the “low risk” compliance rate（P>0.05）. Conclusions Our result show that the quality of animal methods in NSFC-funded Chinese medicine field is low, and the methodological quality has not been improved with the publication of SYRCLE bias risk tool.
- traditional Chinese medicine /
- animal experiment /
- methodological quality /
- national natural science foundation of China （NSFC）

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参考文献(26)

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文章访问数: 128
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NSFC资助中医药领域发表的中文动物实验方法学质量的回顾性分析

作者简介: 周罡和廖绪亮为共同第一作者。周罡（1980-）,男,兰州人,主治医师,硕士研究生,以心血管疾病机制及诊疗为主要研究方向。廖绪亮（1997-）,男,四川德阳人,本科生,以临床医学和系统评价方法学为主要研究方向。

通讯作者: 马彬, Tel: 13919988858, E-mail: mab@lzu.edu.cn

计量

出版历程

The Methodological Quality of NSFC-Funded Animal Experiments in The Field of Traditional Chinese Medicine Published in Chinese Journals: A Retrospective Study

计量

出版历程

目录

作者简介:
周罡和廖绪亮为共同第一作者。周罡（1980-）,男,兰州人,主治医师,硕士研究生,以心血管疾病机制及诊疗为主要研究方向。廖绪亮（1997-）,男,四川德阳人,本科生,以临床医学和系统评价方法学为主要研究方向。

通讯作者:
马彬, Tel: 13919988858, E-mail: mab@lzu.edu.cn