Abstract: Cardiac metastases were rare and mostly originated from distant metastases of some advanced malignant tumors. In the process of clinical diagnosis and treatment, most cardiac metastases were easy to be misdiagnosed and missed when the tumor history was unknown. In this report, a case of cardiac metastasis from lung squamous cell carcinoma misdiagnosed as acute myocardial infarction was discussed, and its clinical features, diagnosis, treatment process, and abnormal electrocardiograph changes were analyzed and summarized.