Abstract: The liver is the most important target organ for blood metastasis of colorectal cancer. 15% ~25% of colorectal cancer patients have liver metastasis at the time of diagnosis. In order to discuss the treatment of liver metastasis of rectal cancer, this paper reported a case of liver metastasis from rectal cancer, who underwent radical resection of rectal cancer by stages. One month after the operation, he received two cycles of neoadjuvant chemotherapy with capecitabine plus oxaliplatin (XELOX) and bevacizumab, and then underwent laparoscopic left hemihepatectomy with fluorescence staining via Glisson pedicle transection. Postoperative pathology showed that there were no cancer cells, indicating pathological complete response (pCR). No recurrence was found in 5 months after the operation.