Abstract: Non-small cell lung cancer (NSCLC) research has been at the forefront of personalized treatment in oncology, with significant results reported in perioperative, locally advanced, and advanced NSCLC. It is important to note that maintaining innovation is a key factor in the development of lung cancer treatment, and it is worth considering how clinical and translational research can be well combined. Therefore, this article will briefly review important translational research, clinical research that will change the practice of NSCLC treatment, and important impactful research advances in 2022.