早期非小细胞肺癌术后复发相关病理学特征及风险预测模型构建的研究现状

    Current Status of Research on Pathological Characteristics Associated With Postoperative Recurrence and Development of Risk Prediction Models in Early-Stage Non-Small Cell Lung Cancer

    • 摘要: 非小细胞肺癌术后复发、转移是早期非小细胞肺癌治疗失败的重要原因,术后复发转移的高危风险因素分析是临床关注的焦点问题。在病理学特征方面,已有较多研究证实,高级别组织病理学亚型、脏层胸膜侵犯、脉管侵犯、气腔播散等是较确切的复发转移高风险因素。在人工智能高速发展时代,构建风险预测模型,有助于准确识别术后复发高风险患者,对患者的辅助治疗以及随访有良好的指导作用。本文重点综述早期肺癌术后复发的相关高风险病理学特征,以及基于病理学特征的风险预测模型的构建现状。

       

      Abstract: Postoperative recurrence and metastasis represent critical causes of treatment failure in early-stage non-small cell lung cancer (NSCLC), with the identification of high-risk factors for postoperative relapse remaining a central focus in clinical research. Pathological characteristics have been extensively investigated, with numerous studies confirming that high-grade histopathological subtypes, visceral pleural invasion, vascular invasion, and spread through air spaces constitute well-established high-risk factors for tumor recurrence and metastasis. In the era of rapidly advancing artificial intelligence, the development of risk prediction models facilitates precise identification of postoperative high-risk patients, thereby providing valuable guidance for adjuvant therapy strategies and follow-up management. This review systematically examines the high-risk pathological features associated with postoperative recurrence in early-stage lung cancer and evaluates current advancements in constructing risk prediction models based on pathological characteristics.

       

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