Correlation between CD209-871A/G Polymorphism and Susceptibility to Tuberculosis: A Meta-Analysis
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摘要: 目的 评价CD209-871A/G位点多态性与结核易感性的相关性。 方法 以“DC-SIGN、CD209、ICAM-3、polymorphism、single nucleotide polymorphism、tuberculosis”为检索词,检索PubMed、EMBASE和Web of Science数据库;以“DC-SIGN、CD209、ICAM-3、结核、多态性”为检索词,检索中国学术期刊全文数据库（CNKI）、中国生物医学文献数据库（CBM）和万方数据库,检索时间截止至2011 年 3 月。全面收集 CD209-871A/G位点多态性与结核易感性的文献。排除不相关研究、会议摘要及综述类文章等,纳入公开发表的病例对照研究,病例组为确诊的结核病患者,无论是否合并人类免疫缺陷病毒感染,对照组为与病例组无血缘关系、无慢性感染性疾病史的健康人群;用 Meta 分析的方法合并比较基因型 AA、GG、AG和等位基因A、G在结核组与对照组中是否有差异。 结果 共纳入3篇文献,共有结核病患者 726例,健康对照 744 例。对总体人群进行 Meta 分析,未发现等位基因G和结核易感性相关[比值比0.60,95%可信区间（0.27,1.35）,P=0.22];基因型AA和等位基因A在结核病与健康对照组之间差异有统计学意义[比值比1.51,95%可信区间（1.01,2.26）,P=0.04;比值比1.28,95%可信区间（1.06,1.55）,P=0.01]。 结论 本研究提示CD209-871AA基因型和等位基因A与结核病的易感性有关,而-871G可能与结核病的机体免疫保护有关,尚需大样本病例对照试验证实。
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关键词:
- 结核易感性 /
- 基因多态性 /
- CD209-871A/G多态性 /
- Meta 分析
Abstract: Objective To assess the correlation of CD209-871A/G polymorphism and susceptibility to tuberculosis. Methods We searched PubMed, EMBASE, Web of Science with retrieval items “DC-SIGN, CD209, ICAM-3, polymorphism, single nucleotide polymorphism, tuberculosis”, and “DC-SIGN, CD209, ICAM-3, tuberculosis, polymorphism” for China Academic Journal, Chinese BioMedical Literature Database, Wanfang Database. We collected all the publications assessing CD209-871A/G polymorphism and susceptibility to tuberculosis, excluded unrelated studies, conference abstracts, summarization and included case-control studies. The case groups were patients diagnosed with tuberculosis regardless of HIV status and the control groups were healthy people without chronic disease. Meta-analysis was performed to check the difference of genotypes including AA, GG, AG and also allele A and G between the two groups. Results A total of 3 studies were included, consisting of 726 tuberculosis patients and 744 healthy people. In the meta-analysis of total population, we did not find allele G related to susceptibility to tuberculosis [OR=0.60, 95%CI（0.27,1.35）, P=0.22]. However, there was a significant difference as to genotype AA [OR=1.51,95%CI（1.01,2.26）,P=0.04] and allele A [OR=1.28,95%CI（1.06,1.55）,P=0.01] in the two groups. Conclusions Genotype AA and allele A were related to susceptibility to tuberculosis, while -871G may be related to host immune protection to tuberculosis, which need to be confirmed by large sample of case-control studies. -
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