Abstract: Objective To evaluate the efficacy and adverse reactions of Desflurane versus Sevoflurane in pediatric anesthesia recovery. Methods We searched PubMed, the Cochrane Library, EMBASE, Chinese Biomedical Database （from establishment to February 2012） for randomized controlled trials （RCTs） about the efficacy and adverse reactions of Desflurane versus Sevoflurane in pediatric anesthesia recovery. Meta-analysis was conducted by RevMan 5.0 software. Result Nine RCTs involving 840 patients were included. The result showed that the early recovery time was shorter in group of Desflurane. There were no significant differences in the postoperative recovery time, postoperative agitation and vomiting （PONV）, severe pain and oculocardiac reflect （OCR） between two groups. Conclusion The limited current evidence shows that the effect of Desflurane is faster than Sevoflurane in early recovery time. The incidence of PONV of Desflurane is higher than Sevoflurane.