ACE2: 心血管疾病潜在的功能基因和生物标志物

Angiotensin-Converting Enzyme 2: Its Potential as A Functional Candidate Gene and A Biomarker for Cardiovascular Disease

摘要: 肾素-血管紧张素-醛固酮系统在心血管疾病的发生发展中起着重要作用,近来发现的肾素-血管紧张素-醛固酮系统新成员血管紧张素转化酶2在心血管组织中普遍存在,通过拮抗血管紧张素转化酶参与心血管功能调控。循环血管紧张素转化酶2活性水平和组织血管紧张素转化酶2表达水平均与心血管疾病密切相关,血管紧张素转化酶2遗传多态性对心血管疾病的发生发展及治疗都有着重要的影响,血管紧张素转化酶2作为潜在的功能基因和生物标志物,将为心血管疾病的防治提供新的靶点。

Abstract: RAAS plays an important role in cardiovascular disease. Recently found ACE2 is prevalent in cardiovascular tissue, which regulates the cardiovascular function through counterwork the ACE. Circulating ACE2 activity and ACE2 transcriptional activity in tissues are closely associated with cardiovascular diseases; ACE2 gene polymorphism has a significant impact on the progression and treatment of cardiovascular diseases. ACE2 as a potential functional gene and biomarker will provide a new target for prevention and treatment of cardiovascular disease.