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    刘金来, 陈璘, 彭朝权, 赵长林, 陈鲁原, 蒋祖勋, 孟素荣, 侯玉清, 熊龙根. 咪达普利与福辛普利治疗原发性高血压患者咳嗽发生率及降压疗效的对照研究[J]. 循证医学, 2005, 5(6): 350-353. DOI: 10.3969/j.issn.1671-5144.2005.06.009
    引用本文: 刘金来, 陈璘, 彭朝权, 赵长林, 陈鲁原, 蒋祖勋, 孟素荣, 侯玉清, 熊龙根. 咪达普利与福辛普利治疗原发性高血压患者咳嗽发生率及降压疗效的对照研究[J]. 循证医学, 2005, 5(6): 350-353. DOI: 10.3969/j.issn.1671-5144.2005.06.009
    shu
    LIU Jin-lai, CHEN Lin, PENG Chao-quan, ZHAO Chang-lin, CHEN Lu-yuan, JIANG Zu-xun, MENG Su-rong, HOU Yu-qing, XIONG Long-gen. Comparative Study on Cough Occurrence and Antihypertensive Efficacy of Imidapril versus Fosinopril in Patients with Essential Hypertension[J]. Journal of Evidence-Based Medicine, 2005, 5(6): 350-353. DOI: 10.3969/j.issn.1671-5144.2005.06.009
    Citation: LIU Jin-lai, CHEN Lin, PENG Chao-quan, ZHAO Chang-lin, CHEN Lu-yuan, JIANG Zu-xun, MENG Su-rong, HOU Yu-qing, XIONG Long-gen. Comparative Study on Cough Occurrence and Antihypertensive Efficacy of Imidapril versus Fosinopril in Patients with Essential Hypertension[J]. Journal of Evidence-Based Medicine, 2005, 5(6): 350-353. DOI: 10.3969/j.issn.1671-5144.2005.06.009
    shu

    咪达普利与福辛普利治疗原发性高血压患者咳嗽发生率及降压疗效的对照研究

    Comparative Study on Cough Occurrence and Antihypertensive Efficacy of Imidapril versus Fosinopril in Patients with Essential Hypertension

      摘要
    • 摘要: 目的比较高血压患者应用咪达普利或福辛普利的咳嗽发生率以及降压疗效.方法采用前瞻性开放、随机交叉对照、多中心研究.原发性高血压患者符合人选标准者,随机分为二组,分别给予咪达普利或福辛普利,观察8周.然后,二组交叉,咪达普利组改服福辛普利,福辛普利组改服咪达普利,继续治疗8周.观察二组的咳嗽发生率和降压疗效.结果试验Ⅰ期(交叉前)咪达普利组咳嗽发生率为10.9%,福辛普利组为17.0%;试验Ⅱ期(交叉后)咪达普利组咳嗽发生率为15.3%,福辛普利组为18.8%,试验Ⅰ期、试验Ⅱ期二组差异无统计学意义(P＞0.

       

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