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    安社娟, 陈志红, 王震, 朱建权, 谢至, 陈世良, 林嘉颖, 郭爱林, 吴一龙. 层粘连蛋白5和表皮生长因子受体在肺癌患者肿瘤组织中的表达关系[J]. 循证医学, 2007, 7(2): 121-124. DOI: 10.3969/j.issn.1671-5144.2007.02.016
    引用本文: 安社娟, 陈志红, 王震, 朱建权, 谢至, 陈世良, 林嘉颖, 郭爱林, 吴一龙. 层粘连蛋白5和表皮生长因子受体在肺癌患者肿瘤组织中的表达关系[J]. 循证医学, 2007, 7(2): 121-124. DOI: 10.3969/j.issn.1671-5144.2007.02.016
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    AN She-juan, CHEN Zhi-hong, WANG Zhen, ZHU Jian-quan, XIE Zhi, CHEN Shi-liang, LIN Jia-ying, GUO Ai-lin, WU Yi-long. Correlations between the Expression Levels of Laminin 5 and Epidermal Growth Factor Receptor in Tumor Tissues of Patients with Lung Cancer[J]. Journal of Evidence-Based Medicine, 2007, 7(2): 121-124. DOI: 10.3969/j.issn.1671-5144.2007.02.016
    Citation: AN She-juan, CHEN Zhi-hong, WANG Zhen, ZHU Jian-quan, XIE Zhi, CHEN Shi-liang, LIN Jia-ying, GUO Ai-lin, WU Yi-long. Correlations between the Expression Levels of Laminin 5 and Epidermal Growth Factor Receptor in Tumor Tissues of Patients with Lung Cancer[J]. Journal of Evidence-Based Medicine, 2007, 7(2): 121-124. DOI: 10.3969/j.issn.1671-5144.2007.02.016
    shu

    层粘连蛋白5和表皮生长因子受体在肺癌患者肿瘤组织中的表达关系

    Correlations between the Expression Levels of Laminin 5 and Epidermal Growth Factor Receptor in Tumor Tissues of Patients with Lung Cancer

      摘要
    • 摘要: 目的 探讨肺癌患者肿瘤组织中层粘连蛋白5(LN5)和表皮生长因子受体(EGFR)表达水平的关系,为EGFR酪氨酸激酶抑制剂(EGFR-TKI)个体化靶向治疗提供依据.方法 应用实时定量PCR方法检测了39例肺癌患者肿瘤组织LN5和EGFR mRNA表达水平,并分析二者之间的关系.结果 Pearson相关分析提示LN5和EGFR表达水平呈正相关(r=0.541,P＜0.000 5).线性回归分析提示EGFR随LN5表达水平的变化而变化,回归方程为:lg EGFR=2.202+0.458 lg LN5。 ......

       

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