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    张再伟, 丁世芳, 赵亚玲, 卢青, 姜娜, 谢琳. 中国人脂联素基因+276G/T单核苷酸多态性与冠心病相关性研究的Meta分析[J]. 循证医学, 2013, 13(1): 61-64. DOI: 10.3969/j.issn.1671-5144.2013.01.012
    引用本文: 张再伟, 丁世芳, 赵亚玲, 卢青, 姜娜, 谢琳. 中国人脂联素基因+276G/T单核苷酸多态性与冠心病相关性研究的Meta分析[J]. 循证医学, 2013, 13(1): 61-64. DOI: 10.3969/j.issn.1671-5144.2013.01.012
    shu
    ZHANG Zai-wei, DING Shi-fang, ZHAO Ya-ling, LU Qing, JIANG Na, XIE Lin. Meta Analysis on the Association between Adiponectin Gene +276G/T Single Nucleotide Polymorphisms and Coronary Atherosclerotic Heart Disease in Chinese Population[J]. Journal of Evidence-Based Medicine, 2013, 13(1): 61-64. DOI: 10.3969/j.issn.1671-5144.2013.01.012
    Citation: ZHANG Zai-wei, DING Shi-fang, ZHAO Ya-ling, LU Qing, JIANG Na, XIE Lin. Meta Analysis on the Association between Adiponectin Gene +276G/T Single Nucleotide Polymorphisms and Coronary Atherosclerotic Heart Disease in Chinese Population[J]. Journal of Evidence-Based Medicine, 2013, 13(1): 61-64. DOI: 10.3969/j.issn.1671-5144.2013.01.012
    shu

    中国人脂联素基因+276G/T单核苷酸多态性与冠心病相关性研究的Meta分析

    Meta Analysis on the Association between Adiponectin Gene +276G/T Single Nucleotide Polymorphisms and Coronary Atherosclerotic Heart Disease in Chinese Population

      摘要
    • 摘要: 目的 探讨中国人脂联素基因+276G/T单核苷酸多态性与冠心病的相关性。 方法 通过文献检索收集2011年12月以前完成或公开发表的中国人脂联素基因+276G/T多态性与冠心病相关性的病例对照研究,剔除不符合要求的文献,以漏斗图检验入选文献的偏倚性,并根据各入选文献结果的同质性检验结果进行数据合并,计算总比值比,Meta分析采用RevMan 4.2.2版软件。 结果 共5篇文献符合纳入条件,入选文献无明显偏倚,各文献间异质性检验显示有关+276G/T等位基因分布情况的文献之间无显著异质性（χ2=4.05,P=0.40）。 Meta分析显示+276G/T基因多态性与冠心病易感性呈相关性（比值比=2.07,95%可信区间1.47~2.92,P<0.000 1）。 结论 中国人群脂联素基因+276G/T单核苷酸多态性与冠心病具有相关性。

       

      Abstract: Objective To explore the association between single nucleotide polymorphisms（SNP） in adiponectin gene +276G/T and coronary atherosclerotic heart disease in Chinese population. Methods Searched relative case-control studies before December 2011, tested publishing bias with funnel plot and meta-analysis with RevMan 4.2.2 software. Results Five case-control studies about +276G/T polymorphism that were based on our inclusion criteria and available in the literature were reviewed. Meta-analysis demonstrated no significant heterogeneity among the studies about allele +276G/T distribution（χ2=4.05, P=0.40）, and significant association between the +276G/T SNP and susceptibility of coronary disease in the Chinese population（OR=2.07, 95%CI 1.47~2.92, P<0.000 1）. Conclusion The current meta-analysis demonstrates a correlation between +276G/T SNP and coronary disease in Chinese population.

       

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