CAO Teng, YANG Bo, WANG Jia-ning, WU Bing, HUANG Dan, QIN Chao-shi, ZHANG Shu-juan. Efficacy of Intermittently Intravenous Levosimendan Infusion on Decompensated Heart Failure: A Meta-AnalysisJ. Journal of Evidence-Based Medicine, 2016, 16(1): 53-59. DOI: 10.12019/j.issn.1671-5144.2016.01.014
Citation:
CAO Teng, YANG Bo, WANG Jia-ning, WU Bing, HUANG Dan, QIN Chao-shi, ZHANG Shu-juan. Efficacy of Intermittently Intravenous Levosimendan Infusion on Decompensated Heart Failure: A Meta-AnalysisJ. Journal of Evidence-Based Medicine, 2016, 16(1): 53-59. DOI: 10.12019/j.issn.1671-5144.2016.01.014
CAO Teng, YANG Bo, WANG Jia-ning, WU Bing, HUANG Dan, QIN Chao-shi, ZHANG Shu-juan. Efficacy of Intermittently Intravenous Levosimendan Infusion on Decompensated Heart Failure: A Meta-AnalysisJ. Journal of Evidence-Based Medicine, 2016, 16(1): 53-59. DOI: 10.12019/j.issn.1671-5144.2016.01.014
Citation:
CAO Teng, YANG Bo, WANG Jia-ning, WU Bing, HUANG Dan, QIN Chao-shi, ZHANG Shu-juan. Efficacy of Intermittently Intravenous Levosimendan Infusion on Decompensated Heart Failure: A Meta-AnalysisJ. Journal of Evidence-Based Medicine, 2016, 16(1): 53-59. DOI: 10.12019/j.issn.1671-5144.2016.01.014
Efficacy of Intermittently Intravenous Levosimendan Infusion on Decompensated Heart Failure: A Meta-Analysis
No content published by the Journal of Evidence-Based Medicine may be reproduced or abridged without authorization. Please do not use or copy the layout and design of the journal without permission.
All articles published represent the opinions of the authors, and do not reflect the official policy of the Journal of Evidence-Based Medicine’ Sponsors or the Editorial Board, unless this is clearly specified.
Objective To discuss the efficacy of intermittently intravenous Levosimendan infusion on decompensated heart failure(DHF). Methods The databases of PubMed,Cochrane Library, Elsevier, Wiley, Web of Science, CNKI, Wanfang database and VIP database were retrieved by using computer for collecting the randomized controlled trials (RCT) until January in 2015 about the treatment of DHF with intermittently intravenous Levosimendan infusion. The long-term efficacy of intermittently intravenous Levosimendan infusion on heart function after DHF was studied through a meta-analysis on extracted data. Results A meta-analysis was conducted in the included 8 RCT, the comparison in all indexes and base values showed that left ventricular ejection fraction (LVEF) increased significantly (WMD=4.27%, 95%CI 2.51%~6.04%) in Levosimendan group, and had statistical difference(P<0.000 01). Short-term and mid-term mortality rate reduced significantly (RR=0.37, 95%CI 0.25~0.45) compared to control group. Level of brain natriuretic peptide (BNP) and New York heart association (NYHA) class function had no statistical significance compared with control group. Conclusions Intermittently intravenous Levosimendan infusion can ameliorate hemodynamic parameters and reduce short-term and mid-term mortality rate.
DownLoad: