A Method of Data Extraction and Meta-Analysis for miRNA-122 in The Diagnosis of Chronic Viral Hepatitis from Healthy

Objective To provide method of data extraction and a meta-analysis for microRNA-122 in the diagnosis of chronic viral hepatitis from healthy. Methods Combination of computer and manual was used to search for literatures in CBM、CNKI、VIP、EMBASE、PubMed database, and the key words HCV, HBV and microRNA-122 were related to inclusion serum levels of microRNA-122 for HBV/HCV. And the software of GetData Graph Digitizer 2.24 was exploited to extract data. Values of sensitivity, specificity and symmetrical receiver operating characteristic curvefor microRNA-122 in the diagnosis of chronic viral hepatitis B/C from healthy were analyzed by stata12 software. Result Six articles were included, and three for diagnosis healthy from HCV, and three for healthy people from HBV. Which involved 321 chronic viral hepatitis patients （112 HCV patients and 209 HBV patients） and 191 healthy controls in our study; The abstracted data of sensitivity and specificity were pooled 0.91 （95%CI 0.83~0.96）, 0.87（95%CI 0.80~0.952） respectively, the area under roc curve of symmetrical receiver operating characteristic curve was 0.93（95%CI 0.90~0.95）. Conclusion We created a repeatability and facticity method of using GetData Graph Digitizer software to extract the date of receiver operating characteristic curve,the extracted data were pooled in our meta-analysis. Meta-analysis showed that serum microRNA-122 can be perfect bio-marker in the diagnosis of chronic viral hepatitis from healthy,especially in the diagnosis of HBV from healthy.