Diagnostic Value of Peripheral Blood Interferon Gamma Release Assays for Tuberculous Pleural Effusion: A Meta-Analysis

Objective To systematically review the diagnostic value of peripheral blood interferon gamma release assays（IGRAs） for tuberculous pleural effusion. Methods We searched PubMed, EMBASE, MEDLINE, Cochrane Library of Foreign Literature and VIP Chinese literature, a comprehensive collection of research-related test for diagnosis of tuberculous pleural effusion on peripheral blood IGRAs from inception to July, 2016.Two reviewers screened literature according to the inclusion and exclusi critera, extracted data, and assessed the quality of included studies. MetaDisc 1.4 were used to conduct the meta-analysis. Results 40 studies included in the final total of 3 306 patients. IGRAs diagnosis of tuberculous pleural effusion pooled sensitivity （SEN） to 0.865 （95%CI 0.848~0.880）; pooled specificity （SPE） was 0.782 （95%CI 0.760~0.803）; pooled diagnostic odds ratio （DOR） to 23.84 （95%CI 16.66~34.13）; area under the summary receiver operating curve （SROC） （AUC） was 0.907 3. Conclusion Peripheral blood IGRAs has a higher diagnostic value of tuberculous pleural effusion.