• 中国科技论文统计源期刊(中国科技核心期刊)
  • 中国医药卫生核心期刊
  • 中国抗癌协会系列期刊
ZHONG Qiao-nan, LIN Xi-na, XI Shao-yan, HE Xin-ming, LIN Xiao-dong, GU Xia. Clinical Significance of BRAFV600E Mutation in Papillary Thyroid Carcinoma[J]. Journal of Evidence-Based Medicine, 2019, 19(6): 349-352. DOI: 10.12019/j.issn.1671-5144.2019.06.008
Citation: ZHONG Qiao-nan, LIN Xi-na, XI Shao-yan, HE Xin-ming, LIN Xiao-dong, GU Xia. Clinical Significance of BRAFV600E Mutation in Papillary Thyroid Carcinoma[J]. Journal of Evidence-Based Medicine, 2019, 19(6): 349-352. DOI: 10.12019/j.issn.1671-5144.2019.06.008

Clinical Significance of BRAFV600E Mutation in Papillary Thyroid Carcinoma

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  • Received Date: August 25, 2019
  • Published Date: December 27, 2019
  • Objective To investigate the expression of BRAFV600E mutation in papillary thyroid carcinoma and analyze its relationship with clinicopathological features. Methods Immunohistochemistry was used to detect the expression of BRAFV600E mutant protein in 244 patients with papillary thyroid carcinoma and adjacent tissues. The relationship between BRAFV600E mutation and clinicopathological parameters was analyzed with clinical pathological data. Results BRAFV600E mutant protein was expressed only in papillary thyroid carcinoma, and the expression rate was 86.48%. The non-tumor tissue adjacent to the tumor was not expressed. The expression rate was 88.89% in classic papillary thyroid carcinoma, 85% in lymph node metastasis group, and 94.64% in capsule invasion group, which were higher than follicular type(78.18%)(χ2=4.176,P=0.041), non-lymph node metastasis group (68.42%)(χ2=4.526,P=0.033) and non-capsule invasion group (84.04%)(χ2=4.145,P=0.042), respectively, and corresponding comparison have significant statistical difference(P<0.05). There were no significant differences between the different tumor diameters, ages, genders and lesions number(P>0.05). Conclusion BRAFV600E mutant protein is highly expressed in papillary thyroid carcinoma, and its expression is significantly associated with lymph node metastasis and capsular invasion. It suggests that BRAFV600E mutation may be associated with tumor invasion and may be a predictor of papillary thyroid carcinoma prognosis.
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