Meta-Analysis on the Association of Interleukin-13（IL-13）Gene Polymorphism and the Genetic Susceptibility of Asthmain Chinese Population

Objective To investigate the association between Interleukin-13（IL-13） gene polymorphism and the genetic susceptibility of asthma. Methods Published data relating to case-control studies reporting the link between IL-13 polymorphisms and asthma in Chinese population were retrieved through Chinese Bio-medicine Database（CBM） and PubMed. Meta-analysis was conducted to determine whether the IL-13 gene polymorphisms were associated with asthma. Results Night studies were finally accepted for analysis. There were four studies focused on C1923T polymorphism, and four studies focused on G2044A polymorphism. One study was focused on both polymorphisms. The odds ratio for asthma for TT/CC genotypes was 4.15 （95%CI 2.83~6.09, P=0.000）, for CT/CC was 1.97 （95%CI 1.53~2.53, P=0.000）. The odds for asthma for AA/GG genotypes was 1.92 （95%CI 1.00~3.72, P=0.051） and for GA/GG was 1.44 （95%CI 1.14~1.82, P=0.000）. There is a publication bias regarding CT/CC genotype （P=0.010）. No significant publication bias was found regarding TT/CC、AA/GG、GA/GG genotypes （P=0.175、0.968、0.633）. Conclusion IL-13 gene +1923TT and +2044GA genotypes should be associated with susceptibility of asthma in China. There was no evidence to confirm that other genotypes in position +1923 and +2044 were associated with asthma in China.