Efficacy of Trimetazidine in Chronic Heart Failure: A Meta-Analysis of Randomized Controlled Trials

Objective To evaluate the efficacy of Trimetazidine in combination with other traditional treatment agents in chronic heart failure patients. Methods We searched the Cochrane Central Register of Controlled Trials, PubMed, EMBASE, and identified randomized controlled trials on the effect of Trimetazidine in patients with chronic heart failure. Results Nine clinical trials meeting our criteria were identified and extracted. Results showed that Trimetazidine significantly reduced the LVEDV 95%CI（-0.48, -0.07）, P=0.008 and LVESV 95%CI（-0.96, -0.48）, P=0.000, and improve LVEF 95%CI（0.99, 1.42）, P=0.000 in chronic heart failure patients. Conclusion The efficacy of Trimetazidine in the treatment of chronic heart failure was confirmed when used with conventional agents, in ischemic or non-ischemic cardiomyopathy.