Meta Analysis on the Association between Adiponectin Gene +276G/T Single Nucleotide Polymorphisms and Coronary Atherosclerotic Heart Disease in Chinese Population

Objective To explore the association between single nucleotide polymorphisms（SNP） in adiponectin gene +276G/T and coronary atherosclerotic heart disease in Chinese population. Methods Searched relative case-control studies before December 2011, tested publishing bias with funnel plot and meta-analysis with RevMan 4.2.2 software. Results Five case-control studies about +276G/T polymorphism that were based on our inclusion criteria and available in the literature were reviewed. Meta-analysis demonstrated no significant heterogeneity among the studies about allele +276G/T distribution（χ²=4.05, P=0.40）, and significant association between the +276G/T SNP and susceptibility of coronary disease in the Chinese population（OR=2.07, 95%CI 1.47~2.92, P<0.000 1）. Conclusion The current meta-analysis demonstrates a correlation between +276G/T SNP and coronary disease in Chinese population.