A Meta-Analysis of Propafenone Versus Amiodarone in Treating Paroxysmal Supraventricular Tachycardia

Objective To evaluate the efficacy and safety of Propafenone and Amiodarone in treating Chinese paroxysmal supraventricular tachycardia （PSVT） cases. Methods We performed the meta-analysis synthesizing the data from previous published studies （up to August 2011） to evaluate the efficacy and safety of Propafenone and Amiodarone in Chinese PSVT cases. Meta-analysis was done using software Review Manager（Version 5.1.4）. Results A total of 8 studies including 561 Chinese cases were identified. The combined ORs（95%CI） of clinical efficiency and incidence of adverse reactions were 0.84（0.40~1.78, P=0.65） and 1.17（0.76~1.79,P=0.48）. Conclusions For Chinese population, the clinical efficiency and incidence of adverse reactions of Propafenone and Amiodarone in treating PSVT were similar. The selection of these two drugs should be based on the patient＇s condition.