Angiotensin-Converting Enzyme 2: Its Potential as A Functional Candidate Gene and A Biomarker for Cardiovascular Disease

RAAS plays an important role in cardiovascular disease. Recently found ACE2 is prevalent in cardiovascular tissue, which regulates the cardiovascular function through counterwork the ACE. Circulating ACE2 activity and ACE2 transcriptional activity in tissues are closely associated with cardiovascular diseases; ACE2 gene polymorphism has a significant impact on the progression and treatment of cardiovascular diseases. ACE2 as a potential functional gene and biomarker will provide a new target for prevention and treatment of cardiovascular disease.