Abstract: Objective To explore the predictive value of plasma soluble OX40 ligand （sOX40L） levels on the major adverse cardiovascular events （MACE） in patients after percutaneous coronary intervention （PCI）. Methods A total of 116 patients with acute coronary syndrome or stable angina pectoris successfully treated with PCI were selected between March 2014 and March 2015. All the patients were followed up for one year after treatement. Study subjects were divided into MACE group and non-MACE group. The plasma sOX40L and other clinical biochemical patameters were detected and their predictive value on MACE was assessed. Results The level of plasma sOX40L was significantly higher in MACE group than that in non-MACE group in statistics （P=0.000）. Multivariate logistic regression analysis revealed that the higher plasma sOX40L level was an independent risk factor of MACE（OR=5.056,P=0.003）. Area under the curve for sOX40L in evaluating prognosis of MACE was 0.782（P<0.001）. The optimal cut off value of sOX40L was 25.79 ng/mL, at the point, the positive predictive value and negative predictive value were 71.4% and 96.8%. Conclusions There are certain predictive value of plasma sOX40L level for the occurrence MACE after PCI. When the level of sOX40L is higher than 25.79 ng/mL, the risk of MACE is greater.