早期乳腺癌患者保乳术后体外部分乳腺加速照射的循证治疗

    Evidence-Based Treatment for Early-Stage Breast Cancer Patients after Breast-Conserving Surgery Treated with External Beam Accelerated Partial-Breast Irradiation

    • 摘要: 目的 应用循证医学方法为1例行保乳术后的早期乳腺癌患者确定放疗方案。 方法 计算机检索PubMed、Cochrane图书馆、CNKI、Wanfang和VIP 数据库,纳入所有关于乳腺癌外照射部分乳腺加速放疗的随机对照试验,放疗技术不限。检索时限均为从建库至2015年10月31 日。 结果 检索到3项随机对照试验。与全乳腺放疗相比,外照射加速部分乳腺放疗能够显著缩短放疗时间、不增加局部复发的风险,但提高美容效果、延长生存时间的作用有限。 结论 外照射加速部分乳腺放疗实现部分早期乳腺癌术后辅助放疗是可行的,但其疗效与远期生存结果仍需随机对照试验进一步研究。

       

      Abstract: Objective To determine the radiotherapy scheme for an early-stage breast cancer patients after breast-conserving surgery based on evidence-based medicine. Methods We searched databases including PubMed, The Cochrane Library, CNKI, Wanfang Database and VIP Database up to October 31, 2015, to collect relevant randomized controlled trials (RCTs) about external beam accelerated partial-breast irradiation for early-stage breast cancer patients with breast-conserving surgery. Radiotherapy techniques were not limiting conditions. Results 3 RCTs were retrieved. Compared with whole breast irradiation, external beam accelerated partial-breast irradiation can significantly shorten the treatment time of radiotherapy and does not increase the risk of local recurrence, while it is limited to improve cosmetic results and to prolong the survival time. Conclusions Adjuvant radiotherapy with external beam accelerated partial-breast irradiation is feasible for some early-stage breast-cancer with breast-conserving surgery, while additional RCTs are needed to assess the long-term efficacy, survival results and toxicity of this approach.

       

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