Abstract: Objective To compare effect of smartphone self-management intervention（SSMI）with usual care（UC） among patients with diabetes by systematic review and meta-analysis. Methods Eligible randomized controlled trials comparing SSMI with UC were searched from PubMed, The Cochrane Library, Web of Science, CNKI database, Wanfang database and VIP database until 30 June 2016. Meta-analyses were conducted to evaluate the clinical effect of HbA1c of SSMI vs. UC. Meta package of R language was used to conducted synthesizingdata（weighted mean difference, WMD）, sensitivity analysis,publication bias analysis. Results There were 2 537 patients including 1 277 in SMMI groups and 1 260 in UC groups involved in 25 studies which were included in the meta-analysis. Self-monitoring and feedback were the main components of SSMI. Compared with UC, SMMI reduced HbA1c more -0.63（95％CI -0.88~-0.39,P<0.001）. Subgroup analyses indicated that the effect sizes were not different among diabetes type,age and follow-up time respectively. Conclusion Compared with usual care, smartphone self-management intervention has better reducing HbA1c effect, which should be a supplementary model of usual care and community-based self-management intervention.