Abstract: Objective To evaluate the efficacy and safety of ultrasonic bone curette application in spinal surgery by meta-analysis. Methods Databases of PubMed, EMBASE, CNKI, VIP and Wanfang data were searched to collect studies that compared the efficacy and safety of ultrasonic bone curette versus conventional instruments in spinal surgery from inception to January 1st 2017. Two reviewers independently screened literature, extracted data, and evaluated the methodological quality of included studies. The meta-analysis was performed using RevMan 5.3 software. Results A total of 8 studies involving 641 patients were included. The results of meta-analysis showed that, compared with conventional instruments, ultrasonic bone curette could reduce operative time (SMD=-2.44, 95%Cl -4.23 to -0.66, P=0.007) and operative blood loss (SMD=-2.31, 95%CI -4.24 to -0.38, P=0.02). But no significant differences were found between two groups in hospitalization (SMD=-0.00, 95%CI -1.22 to 1.21, P=0.99), recovery rate (OR=0.94, 95%CI 0.43 to 2.10, P=0.89) and postoperative complications (OR=0.96, 95%CI 0.47 to 1.95, P=0.90). Conclusion The current evidence shows that ultrasonic bone curette application in spinal surgery is effective and safe, it can reduce operative time and operative blood loss. But compared with conventional instruments, ultrasonic bone curette has no significant advantages in hospitalization, recovery rate and complications. Due to the limited quality of the included studies, more studies are needed to verify the above conclusion.