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GPⅢa基因PIA1/A2多态性与急性脑梗死相关性的系统评价

牛文秀, 尹榕, 杨志奇, 岳金斌

牛文秀, 尹榕, 杨志奇, 岳金斌. GPⅢa基因PIA1/A2多态性与急性脑梗死相关性的系统评价[J]. 循证医学, 2018, 18(4): 241-250. DOI: 10.12019/j.issn.1671-5144.2018.04.013
引用本文: 牛文秀, 尹榕, 杨志奇, 岳金斌. GPⅢa基因PIA1/A2多态性与急性脑梗死相关性的系统评价[J]. 循证医学, 2018, 18(4): 241-250. DOI: 10.12019/j.issn.1671-5144.2018.04.013
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NIU Wen-xiu, YIN Rong, YANG Zhi-qi, YUE Jin-bin. Correlation between The PIA1/A2 Polymorphism of Glycoprotein Ⅲa and Acute Stroke: A Meta-Analysis[J]. Journal of Evidence-Based Medicine, 2018, 18(4): 241-250. DOI: 10.12019/j.issn.1671-5144.2018.04.013
Citation: NIU Wen-xiu, YIN Rong, YANG Zhi-qi, YUE Jin-bin. Correlation between The PIA1/A2 Polymorphism of Glycoprotein Ⅲa and Acute Stroke: A Meta-Analysis[J]. Journal of Evidence-Based Medicine, 2018, 18(4): 241-250. DOI: 10.12019/j.issn.1671-5144.2018.04.013
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GPⅢa基因PIA1/A2多态性与急性脑梗死相关性的系统评价

  • 兰州军区兰州总医院神经内科, 兰州 730050

基金项目: 甘肃省自然科学基金资助项目（1506RJZA302）
详细信息
    作者简介:

    牛文秀（1988-）,女,甘肃白银人,医师,医学学士,神经内科专业。

    通讯作者:

    尹榕,Tel:0931-8994501

  • 中图分类号: R743.33

Correlation between The PIA1/A2 Polymorphism of Glycoprotein Ⅲa and Acute Stroke: A Meta-Analysis

  • Department of Neurology, Lanzhou Military Region General Hospital, Lanzhou 730050, China

摘要

    摘要
  • 摘要: 目的 采用Meta分析的方法评价血小板糖蛋白Ⅲa基因PIA1/A2多态性与急性脑梗死的相关性。 方法 检索 PubMed、EMBASE、Web of Science、Cochrane 图书馆、中国生物医学文献数据库及世界卫生组织临床注册平台,查找2017年7月以前关于GPⅢa基因PIA1/A2多态性与急性脑梗死相关性的病例对照研究。应用RevMan5.2软件完成Meta分析。 结果 共纳入29篇病例对照研究,包括7 036例脑梗死病例和8 484例对照者。分析数据得出以下结论:①GPⅢa基因PIA1/A2多态性与急性脑梗死发病风险相关性无统计学意义[比值比=1.09,95%可信区间（0.91,1.30）,P=0.36]。②GPⅢa基因PIA1/PIA2多态性与不同人种及地区的脑梗死发病风险相关性无统计学意义:欧洲人群的比值比=0.96,95%可信区间（0.79,1.15）,P=0.64;亚洲人群的比值比=1.64,95%可信区间（0.86,3.12）,P=0.13;美洲人群的比值比=0.98,95%可信区间（0.76,1.26）,P=0.85;整体分析结果的比值比=1.03,95%可信区间（0.88,1.22）,P=0.69。③GPⅢa基因PIA1/A2多态性与脑梗死病因的相关性无统计学意义:大动脉粥样硬化型的比值比=1.97,95%可信区间（0.82,4.76）,P=0.13;小动脉闭塞型的比值比=1.10,95%可信区间（0.78,1.55）,P=0.59;心源性栓塞型的比值比=0.85,95%可信区间（0.64,1.14）,P=0.27; 整体分析结果的比值比=1.21,95%可信区间（0.84,1.75）,P=0.31。④GPⅢa基因PIA1/A2多态性与≤45岁脑梗死患者的发病风险相关性无统计学意义[比值比=0.96,95%可信区间（0.72,1.27）,P=0.78]。 结论 GPⅢa基因PIA1/A2多态性并不增加急性脑梗死的发病风险,且与人种、地区及年龄均无关,同时与引起脑梗死的不同病因无直接相关性。
    Abstract: Objective To evaluate the relationship between glycoprotein Ⅲa gene PIA1/A2 polymorphism and acute stroke by meta-analysis. Methods The case-control studies about the correlation between the PIA1/A2 polymorphism of glycoprotein Ⅲa and acute stroke were retrieved from PubMed, EMBASE, Web of Science, Cochrane Library, China Biology Medicine disc and clinical trial before July 2017. And we analyzed the data using Review Manager （version 5.2）. Results 29 case-control studies were included,involving 7 036 stroke patients and 8 484 controls. After data analysis the conclusion were following aspects:①There was no statistical significance between the PIA1/A2 polymorphism of glycoprotein Ⅲa and acute stroke[OR=1.09,95%CI（0.91,1.30）,P=0.36]. ②There was no statistical significance between the PIA1/A2 polymorphism of glycoprotein Ⅲa and acute stroke within different ethnic or region, including European [OR=0.96, 95%CI（0.79, 1.15）,P=0.64],Asian [OR=1.64, 95%CI（0.86,3.12）, P=0.13] and American[OR=0.98, 95%CI（0.76,1.26）,P=0.85]. Overall analysis results[OR=1.03, 95%CI（0.88, 1.22）,P=0.69]. ③It showed that there was no statistical significance between the PIA1/A2 polymorphism of glycoproteinⅢa and the pathogeny of stroke. Large artery atherosclerosis [OR=1.97, 95%CI（0.82, 4.76）, P=0.13], small artery occlusion [OR=1.10, 95%CI（0.78, 1.55）, P=0.59], cardiac embolism [OR=0.85, 95%CI（0.64, 1.14）, P=0.27], Overall analysis results [OR=1.21, 95%CI（0.84, 1.75）,P=0.31]. ④There was no statistical significance between the PIA1/A2 polymorphism of glycoprotein Ⅲa and stroke patients of age less than or equal to 45 [OR=0.96, 95%CI（0.72, 1.27）,P=0.78]. Conclusion To date, it has not found the PIA1/A2 polymorphism of glycoproteinⅢa is the risk of acute stroke. The PIA1/A2 polymorphism of glycoprotein Ⅲa has no correlation with race, region, age and the pathogeny of stroke.
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  • 收稿日期:  2017-07-12
  • 发布日期:  2018-08-27

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