Abstract: Objectives To investigate the difference of carotid atherosclerosis between patients with cerebral infarction and healthy subjects by superb micro-vascular imaging（SMI）, and to evaluate the diagnostic value of SMI in carotid artery lesions. Methods The research group selected 50 patients with cerebral infarction in our hospital, and 50 healthy people were selected as control group, two groups were performed with conventional carotid artery scan and recorded carotid plaque location, size, shape, internal echo, and the number of carotid plaques. Use SMI to observe the plaque of neovascular situation, comparison of plaque of patients with cerebral infarction and healthy subjects on carotid plaque neovascularization in detection rate. Results Most of the carotid plaques in the patients with cerebral infarction were irregular soft spots （58%,29/50） and mixed plaque （40%, 21/50）, accompanied by different degrees of carotid stenosis （the incidence of severe stenosis was 22%）, and the detection rate of neovascularization in the plaque was significantly higher than that of the healthy persons （χ²=12.70, P<0.05）. Conclusions Using SMI technology can effectively evaluate the stability of carotid plaque, guide the clinical practise to take the correct prevention and treatment measures to prevent or reduce the occurrence of stroke events.