Abstract: Cardiovascular diseases has become the most important public health issue in China, and new diagnostic and therapeutic methods are urgently needed to improve the level of prevention and treatment of cardiovascular diseases. Exosomes are membrane-derived nanovesicles secreted by different cells, which mediate cell-to-cell communication by transporting vesicle contents （proteins, nucleic acids, etc.） and widely participate in the pathophysiological process. Renin-angiotensin system （RAS） is an important humoral regulation system in human body and plays an important role in the occurrence and development of cardiovascular diseases. Studies have shown that exosomes interact with RAS, collectively participate in the pathological process of cardiovascular diseases. In this review, we summarize the research status of the interaction between exosomes and RAS in cardiovascular diseases.