Abstract: In China, next generation sequencing（NGS） has became a common molecular testing tool used by clinical oncologists, however, NGS clinical reports could be overwhelming for some clinicians who are unfamiliar with NGS. Approximately 90% of clinicians are dependent on external support for the interpretation of NGS reports. In order to improve the clinicians' ability to interpret and derive more information from NGS reports, a working group comprised of clinical oncologists and NGS professionals from all over China have compiled relevant standards and guidelines to equip the clinicians with the knowledge to identify the key information and avoid the over-interpretation of genomic information from NGS clinical reports. This article provides a detailed introduction on the logically structured evidenced-based principles of NGS reports including the interpretation of somatic mutations related to clinical targets or driver genes, the proper interpretation of genomic results to inform clinical decision-making, reportable scope, sample quality control, and other relevant information included in NGS clinical reports. With a better grasp on the information from NGS reports, the clinicians should be able to integrate the basic clinical information, other past or present test results, and the molecular profile of the patient to comprehensively assess the patient's disease and tailor a treatment strategy that will benefit the patient.