Abstract: Objective To investigate the expression and clinical significance of LncRNA BC200 in colorectal cancer. Methods From June 2018 to June 2020, 90 patients with colorectal cancer in Shenzhen Shekou People's Hospital were selected as the research objects. Fresh cancer tissues and adjacent tissues （normal colorectal tissues confirmed by pathology） were collected and treated with liquid nitrogen freezing and paraffin embedding respectively. The expression of LncRNA BC200 was detected by reverse transcription-polymerase chain reaction （RT-PCR） and vascular endothelial growth factor （VEGF） was detected by immunohistochemistry （IHC）. The difference of LncRNA BC200 expression level and VEGF positive expression score in cancer tissues and adjacent tissues was compared. The correlation between LncRNA BC200 expression and VEGF positive expression score was analyzed. Results The RT-PCR results showed that the relative expression levels of LncRNA BC200 in colorectal cancer tissue and adjacent tissues were （3.64±0.73） and （1.17±0.55）. The expression of LncRNA BC200 in colorectal cancer tissues was significantly higher than that in adjacent tissues （t=7.334, P<0.001）. The relative expression levels of VEGF in colorectal cancer tissues and adjacent tissues were （5.25±0.26） and （2.16±0.11）. The expression levels of VEGF in colorectal cancer tissues were significantly higher than those in adjacent tissues, and the difference was statistically significant （t=8.224, P<0.001）. The results of IHC staining showed that the positive expression score of VEGF in colorectal cancer tissue was higher than that in adjacent tissues （t=5.372, P<0.001）. There was no significant difference in the relative expression of LncRNA BC200 in colorectal cancer tissues of different gender and tumor location （P>0.05）, but the expression of LncRNA BC200 was significantly different in colorectal cancer tissues with different clinical stages, different degrees of differentiation and whether lymph node metastasis occurs （P<0.05）. There was a positive correlation between the relative expression of LncRNA BC200 and the score of VEGF positive expression （r=0.703, P<0.05）. Conclusions The expression of LncRNA BC200 was significantly increased in colorectal cancer. The expression of LncRNA BC200 was related to the clinical stage, differentiation degree and lymph node metastasis of colorectal cancer patients, and was positively correlated with the expression of angiogenesis related factor VEGF.