Abstract: Objective Evaluation of other proton pump inhibitor （PPI） is made by comparing with Omeprazole on the efficacy of the treatment of gastroesophageal reflux disease（GERD）, and providing the evidence-based for clinic use of drug. Method Search the clinical randomized controlled trials references of Esomeprazole, Pantoprazole, Rabeprazole, Lansoprazole compared with Omeprazole on treatment of GERD published home and abroad, mainly in the cure rate of Esophagitis and symptoms （mainly heartburn） remission rate for the evaluation of indicators, and use meta-analysis software RevMan4.2 in Cochrane Collaboration to data processing and analysis. Result Totally 6 pieces of reference paper selected. Analysis of results showed that the total sample size cure of rate of gastric esophagitis surpassed 6 825, in which the treatment group for 3 430, the control group for 3 395, after 4 weeks: P=0.05, statistically significant, odds ratio OR=1.32, 95% confidence interval for （1.00,1.73）; after 8 weeks: P>0.05, not statistically significant, odds ratio OR=1.25, 95% confidence interval for （0.74,2.10）; treatment symptoms （mainly heartburn） remission rate of the total sample size for 5 642, one of the treatment group for 2 826, the control group for 2 816, P<0.05, statistically significant, odds ratio OR=1.43, 95% CI （1.28,1.59）. Conclusions In the treatment of Esophagitis after 4 weeks the cure rate and post-treatment symptoms （mainly heartburn） remission rate, other PPI had better efficacy than Omeprazole; and 8 weeks later, the treatment of the recovery rates of other PPI and Omeprazole were similar in terms of efficacy.