Abstract: Objective To investigate and develop a special data base software for the large bowel carcinoma and to realize the disposal,sharing and communication for the large bowel carcinoma it shall form the base of information service system for clinical and research. Methods To use the NET as the operation system, and combine Microsoft SQL Server as date base system. Current popular C/S structure at present, WINDOWS operation system act as platform, language environment VISULA BASIC compile server program. We selected more than two hundred relative indexes as basic parameter for designing this software after referring to information at home and abroad. Result This software can achieve all the function of wordlike operation. Simplifying the methods of input we can refer to the embeded international stage system for large bowel and common tool whenever necessary and stage correctly.It also can accomplish picture upload,insert, store and associate with this patient information. There is no need to amend program for the change of some parameters. Conclusion By using this software we can handle the information of large bowel promptly, correctly, standardly, systematically, and generalizationally. The incorrect stage of large bowel cancer shall never happen. It also can extend database resources, realize the sharing and increase the availability factor of this resource with the joint efforts of several hospitals or several regions. It will form the basic work of information service system for clinical and research as well.