Abstract: Objective Methods of evidence-based medicine were used to make an individualized treatment plan concerning primary hypertension complicating unstable angina in elderly patients. Methods After clinical problems were put forward, evidence was collected from MEDLINE （PubMed 2002-2011）and National Guideline Cleating-house （NGC）. Subject words were: primary hypertension; acute coronary syndrome（ACS）; evidence-based treatment; meta-analysis; systematic review; randomized controlled trial. Results A total of 120 RCTs （only items with links to full text）, and 61 systematics reviews were identified （only items with links to full text）. A rational treatment plan was made upon a serious evaluation of the date. After 24 hours of blood pressure care in hospital.The plan was proved optimal. Conclusion The treatment efficacy in newly diagnosed primary hypertension complicating with unstable angina in old patients has been improved by determining an individualized treatment plan according to evidence-based methods.