Abstract: Objective To evaluate the differences of the changes of pulse wave velocity（PWV） of hypertension patients with the treatment of calcium channel blockers or Renin-angiotensin system blockers. Methods Based on the principles of evidence-based medicine, corresponding inclusion and exclusion criteria, along with search strategies were developed. We searched the Ovid EMB Reviews, PubMed, EMBASE, Chinese Biomedical Literature Database, Chinese Scientific Journal Full-text Database, and Chinese Journal Full-text Database up to January 2012 to identify randomized controlled trials comparing the effects of calcium channel blockers with that of Renin-angiotensin system blockers on arterial stiffness of hypertension patients after more than 12 weeks treatment. Analyzed the data by Cochrane Collaboration’s RevMan 5.0 software. We performed the comparisons of the effects of calcium channel blockers and Renin-angiotensin system blockers on arterial stiffness, systolic blood pressure, diastolic blood pressure and pulse pressure in hypertension patients. Results Seven randomized controlled trials involving 524 patients were included. The results of meta analysis showed that Renin-angiotensin system blockers was better than calcium channel blockers in reducing arterial stiffness （MD=160.15, 95%CI 57.10~263.21）, but it was weaker than calcium channel blockers in reducing systolic blood pressure （MD=-2.94, 95%CI-4.59~-1.29）and diastolic blood pressure （MD=-6.63, 95%CI -9.56~-3.70）. There is no significant difference in pulse pressure between the two drugs （MD=-6.12,95%CI-2.3~14.55）. Conclusions The effect of Renin-angiotensin system blockers is stronger than that of calcium channel blockers on reducing arterial stiffness in hypertension patients, and was independent of reduction in blood pressure by these drugs.