Abstract: With a sharp rise in the incidence and mortality of tumor, studies have gradually been hotter. Tumor data has the characteristics of being vast, disorderly, and inconvenient to retrieve. Tumor registry database is born as the product of the development of evidence-based medicine, which is more suitable for the organization management and fast query retrieval of a large number of disordered tumor-related data. This paper highlights the SEER database and sums up existing problems in clinical application of the tumor registry database at home and abroad.