Abstract: Among numerous malignant tumors, the incidence and mortality of hepatocellular carcinoma （HCC） are high, and as a kind of radical treatment, radiofrequency ablation （RFA） has been widely used in the treatment of HCC. It is necessary to sum up reports in recent years and to conclude the major influence factors of long-term curative effect of RFA treatment in order to help physicians make better clinical decisions and to improve survival rates of patients with HCC.