Abstract: Objective To compare perioperative and postoperative outcomes of laparoendoscopic single-site (LESS-RN) radical nephrectomy and conventional laparoscopic radical nephrectomy (CL-RN). Methods PubMed, MEDLINE, EMBASE, ISI Web of Knowledge and Cochrane Library databases were searched for studies released prior to October 2014. References of included studies were also searched to identify additional and potentially relevant studies. And we analyzed the data using Review Manager (version 5.1). Results 10 retrospective comparative studies and 1 prospective comparative study were included, involving 551 patients. LESS-RN group showed longer operative time but lower estimated blood loss (EBL), VAS pain score and analgesics requirement. It also had shorter hospital stay and time to recover to diet (P<0.01). No significant difference was found in terms of complications, conversion, transfusion, incision length, Hb decrease, creatinine increase, negative margins and recurrence (P>0.05). Patients’ satisfaction was significantly better (P<0.01) in LESS-RN group. Condusion Laparoendoscopic single-site radical nephrectomy showed comparable outcomes to conventional laparoscopic radical nephrectomy, and it has less pain, blood loss and takes shorter to recover, showing advantages in patients’ satisfaction for cosmesis.