Abstract: Objective To systematically review preventive effect that intracuff Lidocaine used in patients receiving general anesthesia endotracheal intubation is associated with significantly reduced incidence of postoperative sore throat, cough and hoarseness. Methods Using the Cochrane systematic review methods, we searched the Cochrane Controlled Trial Registers （CCTR） of the Cochrane Library, PubMed, EMBASE, CNKI and Wanfang databases from inception to October 2015. We also handsearched relevant journals and conference proceedings. Two reviewers independently selected studies and assessed the quality of the trials. Disagreements were resolved by discussion, in consultation with a third reviewer. Then, meta-analysis was performed using RevMan 5.1 software. Results Thirteen trials involving 982 patients were finally included. Meta analysis results show that the number of sore throat that occurred in the postoperative 1 h in the test group were less than the control group OR=0.31,95%CI （0.17, 0.57）,P=0.000 2; the number of test group postoperative sore throat in 24 h occurred less than the control group OR=0.34,95%CI（0.17,0.68）,P=0.002. The severity score of postoperative sore throat in the 1 h was less in test group than in control group WMD=-18.08,95%CI（-26.05,-10.11）,P<0.000 01; The severity score of postoperative sore throat in the 24 h was less in test group than in control groupWMD=-10.11,95%CI （-12.13, -8.08）,P<0.000 01. The incidence of cough in the recovery period was compared with control group, and the incidence of cough in the experimental group was less than control group OR=0.26,95%CI（0.13,0.53）,P=0.000 2. In postoperative 24 h, the incidence of hoarseness in the test group occurred less OR=0.29,95%CI（0.11,0.75）,P=0.01. Conclusion The intracuf Flidocaine can be effective in preventing postoperative sore throat, hoarseness and choking cough for general anesthesia under tracheal intubation patients.