Abstract: Objective The research aimed to provide reference and guidelines for the development of ESI molecular biology and genetics in domestic universities and research institutions, and to provide suggestions for researchers in the field of bibliometrics. Methods This paper chooses the Top20 benchmark institutions in mainland China, Hongkong and Taiwan as the research object, and uses the bibliometrics method to analyze the development trend of the data in the past 10 years. There are five aspects of dimensions: scientific research productivity, scientific research influence, periodicals, published author statistics, international cooperation papers. Results and Conclusions Analysis and comparison of the mainland, Hongkong and Taiwan Top20 institutions in scientific research productivity, scientific research and international exchanges and cooperation in the development of the situation and trends, the conclusions included that the mainland institutions in the discipline of better scientific output, the selected Hongkong institutions' scientific research influence stronger, and the level of international cooperation in the development of institutions faster.