Abstract: Objective To evaluate the relationship between glycoprotein Ⅲa gene PIA1/A2 polymorphism and acute stroke by meta-analysis. Methods The case-control studies about the correlation between the PIA1/A2 polymorphism of glycoprotein Ⅲa and acute stroke were retrieved from PubMed, EMBASE, Web of Science, Cochrane Library, China Biology Medicine disc and clinical trial before July 2017. And we analyzed the data using Review Manager （version 5.2）. Results 29 case-control studies were included,involving 7 036 stroke patients and 8 484 controls. After data analysis the conclusion were following aspects:①There was no statistical significance between the PIA1/A2 polymorphism of glycoprotein Ⅲa and acute strokeOR=1.09,95%CI（0.91,1.30）,P=0.36. ②There was no statistical significance between the PIA1/A2 polymorphism of glycoprotein Ⅲa and acute stroke within different ethnic or region, including European OR=0.96, 95%CI（0.79, 1.15）,P=0.64,Asian OR=1.64, 95%CI（0.86,3.12）, P=0.13 and AmericanOR=0.98, 95%CI（0.76,1.26）,P=0.85. Overall analysis resultsOR=1.03, 95%CI（0.88, 1.22）,P=0.69. ③It showed that there was no statistical significance between the PIA1/A2 polymorphism of glycoproteinⅢa and the pathogeny of stroke. Large artery atherosclerosis OR=1.97, 95%CI（0.82, 4.76）, P=0.13, small artery occlusion OR=1.10, 95%CI（0.78, 1.55）, P=0.59, cardiac embolism OR=0.85, 95%CI（0.64, 1.14）, P=0.27, Overall analysis results OR=1.21, 95%CI（0.84, 1.75）,P=0.31. ④There was no statistical significance between the PIA1/A2 polymorphism of glycoprotein Ⅲa and stroke patients of age less than or equal to 45 OR=0.96, 95%CI（0.72, 1.27）,P=0.78. Conclusion To date, it has not found the PIA1/A2 polymorphism of glycoproteinⅢa is the risk of acute stroke. The PIA1/A2 polymorphism of glycoprotein Ⅲa has no correlation with race, region, age and the pathogeny of stroke.