Abstract: Objective To explore the effect of health education prescription combined with patient record intervention in patients with nasopharyngeal carcinoma during radiotherapy. Methods 71 patients with nasopharyngeal carcinoma were randomly divided into intervention group （n=35） and control group （n=36）. The control group was given radiotherapy, routine nursing and health education. On this basis, the intervention group used health education prescription combined with patient record book intervention. The correct execution rate of gargle and the cases of radiation oral mucositis after 30 Gy radiotherapy and at the end of radiotherapy were compared between the two groups. Results The correct execution rate of gargle in the intervention group and the control group was 91.4% and 55.6%, respectively. In the intervention group and control group, the incidence of grade Ⅰstomatitis was 2.8% and 28%, respectively, and the incidence of grade Ⅱ stomatitis was 0% and 2.7% after 30 Gy radiotherapy. At the end of radiotherapy, the incidence of grade Ⅰ stomatitis in the intervention group and control group was 23% and 47%, the incidence of grade Ⅱ stomatitis was 11% and 28%, the incidence of grade Ⅲ stomatitis was 0% and 5.5%, respectively. The incidence of radiation oral mucositis in the intervention group was significantly lower than that in the control group （P < 0.05）. Conclusion The application of health education prescription combined with the intervention of patient record book can improve the compliance of patients and the ability of execution of doctors' orders, thus reducing the degree of radiation oral mucositis and reducing the incidence of radioactive oral mucositis in patients with nasopharyngeal carcinoma.