Abstract: Objective To analyze the rationality of postoperative treatment plan of colon cancer in Jingxian Hospital, and provide beneficial reference for further standardizing the postoperative treatment plan of colon cancer. Methods Screening of 164 cases of colon cancer in Jingxian Hospital with postoperative adjuvant chemotherapy, summarized the chemotherapy scheme selection, dose accuracy, treatment sufficiency, the incidence of adverse reactions, different departments treatment comparison, aspects of statistics, on the basis of the comprehensive evaluation of the rationality of adjuvant therapy after colon cancer surgery, the causes of unreasonable treatment were summarized and analyzed. Result 125 cases （76.22%）of chemotherapy scheme selection conforms to the guidelines recommend, 77 cases （46.95%）of the dosage in accordance with guidelines recommended, 95 cases（57.93%） of chemotherapy treatment course in accordance with guidelines recommend, 81 cases （49.39%） finished the cycle of chemotherapy in six months. In the oncology department, the rational rate of chemotherapy plan, the reasonable rate of treatment course, and the completion period chemotherapy were completed in 6 months. The reasonable rate of three statistical indicators was significantly higher than that of the non-oncology department （P < 0.01）. It shows that the non-standard adjuvant chemotherapy after colon cancer surgery is more serious, and there is still a huge space for improvement. Conclusions Colon cancer postoperative adjuvant chemotherapy scheme should follow large-scale clinical trials and related guidelines recommend, strict control of drug dosage, concrete usage, full course chemotherapy, active prevention and treatment of adverse drug reactions associated with chemotherapy, timely evaluation of curative effect, avoid excessive or insufficient treatment etc. Especially in non-oncology departments, doctors should be strictly standardized in the above aspects, safety and effective implementation of adjuvant chemotherapy for colon cancer patients from multiple perspectives.