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    李扬秋, 杨力建, 陈少华, 李萡. 从炎症调节因子到肿瘤抑制因子——A20的特点及其在淋巴细胞肿瘤发生中的作用[J]. 循证医学, 2011, 11(1): 54-59. DOI: 10.3969/j.issn.1671-5144.2011.01.022
    引用本文: 李扬秋, 杨力建, 陈少华, 李萡. 从炎症调节因子到肿瘤抑制因子——A20的特点及其在淋巴细胞肿瘤发生中的作用[J]. 循证医学, 2011, 11(1): 54-59. DOI: 10.3969/j.issn.1671-5144.2011.01.022
    shu
    LI Yang-qiu, YANG Li-jian, CHEN Shao-hua, LI Bo. From Inflammation Regulator to Tumor Suppressor——The Feature of A20 and Its Role in the Initiation of Lymphocytic Malignancy[J]. Journal of Evidence-Based Medicine, 2011, 11(1): 54-59. DOI: 10.3969/j.issn.1671-5144.2011.01.022
    Citation: LI Yang-qiu, YANG Li-jian, CHEN Shao-hua, LI Bo. From Inflammation Regulator to Tumor Suppressor——The Feature of A20 and Its Role in the Initiation of Lymphocytic Malignancy[J]. Journal of Evidence-Based Medicine, 2011, 11(1): 54-59. DOI: 10.3969/j.issn.1671-5144.2011.01.022
    shu

    从炎症调节因子到肿瘤抑制因子——A20的特点及其在淋巴细胞肿瘤发生中的作用

    From Inflammation Regulator to Tumor Suppressor——The Feature of A20 and Its Role in the Initiation of Lymphocytic Malignancy

      摘要
    • 摘要: A20是炎症信号传导的中心调节因子—NF-κB抑制因子,而近年研究发现A20更重要的功能是作为一个肿瘤抑制因子,其缺失在淋巴细胞肿瘤的发生中有重要的作用。综述近年所报道的A20生物学功能、分子机制及其在淋巴细胞肿瘤中调节作用的研究进展。

       

      Abstract: A20 was originally identified as a key regulator of inflammation signalling pathways, a NF-κB inhibitor. Recently, A20 has also been proposed to function as a tumor suppressor. Lacking A20 is involved in tumorigenesis in several human B-cell lymphomas. In this review, current knowledge concerning the feature of A20 biological activities, as well as the underlying molecular mechanisms, and the regulating role of A20 in lymphocytic malignancies is summarized.

       

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