毛晓韵, 金锋, 王坤. 多西紫杉醇联合贝伐单抗或安慰剂在HER2阴性转移性乳腺癌中的Ⅲ期临床研究[J]. 循证医学, 2012, 12(3): 144-146. DOI: 10.3969/j.issn.1671-5144.2012.03.014
    引用本文: 毛晓韵, 金锋, 王坤. 多西紫杉醇联合贝伐单抗或安慰剂在HER2阴性转移性乳腺癌中的Ⅲ期临床研究[J]. 循证医学, 2012, 12(3): 144-146. DOI: 10.3969/j.issn.1671-5144.2012.03.014
    MAO Xiao-yun, JIN Feng, WANG Kun. Phase Ⅲ Study of Bevacizumab plus Docetaxel Compared with Placebo plus Docetaxel for the First-Line Treatment of Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer[J]. Journal of Evidence-Based Medicine, 2012, 12(3): 144-146. DOI: 10.3969/j.issn.1671-5144.2012.03.014
    Citation: MAO Xiao-yun, JIN Feng, WANG Kun. Phase Ⅲ Study of Bevacizumab plus Docetaxel Compared with Placebo plus Docetaxel for the First-Line Treatment of Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer[J]. Journal of Evidence-Based Medicine, 2012, 12(3): 144-146. DOI: 10.3969/j.issn.1671-5144.2012.03.014

    多西紫杉醇联合贝伐单抗或安慰剂在HER2阴性转移性乳腺癌中的Ⅲ期临床研究

    Phase Ⅲ Study of Bevacizumab plus Docetaxel Compared with Placebo plus Docetaxel for the First-Line Treatment of Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer

    • 摘要: 化疗是HER2阴性转移性乳腺癌的有效一线治疗方法, 针对肿瘤血管生成关键步骤及分子的抗肿瘤血管生成靶向治疗是继HER2靶向治疗后的另一重要的靶向治疗。贝伐单抗(Bevacizumab)为抗血管内皮生长因子的人源化单克隆IgG抗体, 与其它抗肿瘤药物联合用于结直肠癌、肺癌、肾癌及乳腺癌的治疗。理论上, 贝伐单抗用于乳腺癌的治疗不受HER2状态的限制, 尤其是HER2阴性的患者。近年来的3项临床研究(E2100、AVADO、RiBBON-1)的结果奠定了贝伐单抗在转移性乳腺癌治疗中的重要地位。

       

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