Abstract: Objective To formulate an individualized evidence-based treatment for a chronic pancreatitis patient with new onset diabetes. Methods We attempted to get the evidences of treatments in pancreatic diabetes, which induced by chronic pancreatitis, by searching MEDLINE, EMBASE, Cochrane library, CBM disc, Wanfang data and CNKI. The evidences were collected and critically assessed after the clinical issues were put forward. Results No clinical guideline was available for the treatment of pancreatic diabetes. With the same purpose of treatment in other types of diabetes, treatments of pancreatic diabetes included basic nutrition therapy, oral agencies for blood glucose control and intensive insulin therapy. Discussions of the use of antidiabetic drugs and insulin were ongoing, and different opinions were detected. Insulin might increase the risk of pancreatic cancer, while metformin reduced this possibility. Conclusion Comprehensive measures should be taken in the management of pancreatic diabetes. Intensive insulin therapy should be applied to patients with high compliance, and avoid the occurrence of severe hypoglycemia. Meanwhile, early tumor detection should be especially noticed with pancreatic diabetes.