Abstract: Objective To assess the diagnostic value of IGRA for latent tuberculosis infection in solid organ transplant recipients. Methods We searched PubMed,EMBASE and Cochrane library to evaluate the evidence of using QuantiFERON-TB Gold in-tube （QFT-IT） and T-SPOT on blood for the diagnosis of latent tuberculosis infection in solid organ transplant recipients. Meta Disc 1.4 was used to handle data from included studies. Results The search identified 6 eligible studies that included 751 transplant recipients before transplantation. Compared with TST, the summary values of specificity,sensitivity, positive likelihood ratio, negative likelihood ratio,OR,and SROC curve of QFT-IT and T-SPOT were 81%,74%,3.94,0.33,12.44,0.847 8 and 78%,75%,3.61,0.32,12.07,0.845 0, respectively. Conclusion IGRA in their current formulations has limited accuracy in diagnosing latent tuberculosis infection in transplant recipients, and should not be used alone to rule out or rule in latent tuberculosis infection in transplant recipients. Further modification is needed to improve their accuracy.